Human Papilloma Virus (HPV) infections are associated with the development of cervical cancer. The goal of the present research is the development of a HPV screening test for risk assessment based on the MultiFinder / SmartFinder technology. This approach allows testing four different risk factors for the development of cervical cancer within one reaction (viral genotype, viral load, viral physical status, en genomic instability).
Theelen W, Speel EJ, Herfs M, Reijans M, Simons G, Meulemans EV, Baldewijns MM, Ramaekers FC, Somja J, Delvenne P, Hopman AH. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay. Am J Pathol. 2010 Oct;177(4):2022-33.